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2009 CompX Grants

Winners of the 2009-2010 Neukom Institute CompX Grants Program for Dartmouth faculty, with awards of up to $20,000 for one-year projects, were:

Integrating Computation and Experiment in Functional Deimmunization of Therapeutic Proteins

Chris Bailey-Kellogg (Computer Science) and Karl E. Griswold (Thayer)

deimmunize process2We are developing an integrated suite of general methods combining computation and experiment in order to produce immunotolerant variants of therapeutic proteins, in which immunogenicity is reduced while therapeutic activity is maintained.  We will use the information gleaned from experimental studies to refine the computational methods, with an eye towards establishing a broadly applicable approach to designing efficacious and non-immunogenic therapeutic proteins.  Video

This CompX grant was seed for external funding for a NIH R01 grant of $1,500,000 for 5 years and a NIH R21 grant of $445,065 for 2 years.

Journal publication:

"Optimization of Therapeutic Proteins to Delete T-Cell Epitopes While Maintaining Beneficial Residue Interactions," Journal of Bioinformatics and Computational Biology, Vol 9, Issue 2 (2011) pp. 207-229; DOI: 10.1142/S0219720011005471

"Optimization algorithms for functional deimmunization of therapeutic proteins," BMC Bioinformatics 2010, 11:180; DOI:10.1186/1471-2105 11-180


GreenLite Dartmouth

Lorie Loeb (Computer Science)

greenlite logoGreenLite Dartmouth combines computation, art, engineering, information visualization, sociology, environmental science, systems thinking and behavioral psychology to turn real-time energy use data into a meaningful display that encourages students to change their behavior and conserve resources. We utilize 2D and 3D animations to reflect historical data and predict what current energy use should be for a given day, time or location. Neukom funds were used for student research to develop a content delivery engine that can implement specified decision trees, implementation of a game engine and Facebook application and to conduct a user study.  Video

This CompX grant was seed for $140,000 from Dartmouth Alum Jake Weinbaum.

Journal publication:

"Emotionally Engaging Students to Change Behaviors and Conserve Resources: Unplug or the Polar Bear Gets it!", International Journal of Environmental, Cultural, Economic and Social Sustainability, Volume 6


Cyber-Physical Networked Systems Testbed

Reza Olfati-Saber (Thayer)

olfati-saberCan intelligent cars with the ability to autonomously drive, change lanes, and avoid collision with nearby vehicles and pedestrians, one day create safer roads with fewer accidents, traffic, and air pollution? Professor Olfati-Saber and his team are using his Comp X Grant to build a mobile sensing platform and robotic testbed for an in-depth study of Cyber-Physical Networked Systems---a technological counterpart of complex systems such as flocks and swarms in nature with cohesive behaviors.   Video

This CompX grant was seed for external funding for a NSF grant of $2,000,000 for 3 years.

Journal publication:

"Coupled Distributed Estimation and Control for Mobile Sensor Networks," IEEE Trans. on Automatic Control, vol. 57(9), Sep. 2012 (to appear).

Last Updated: 10/2/13